Dimethyl Sulfate → 8-(5-Hydroxypentylamino) caffeine

反応式

[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]1[NH:17][C:16]2[C:15](=[O:18])[N:13]([CH3:14])[C:12](=[O:19])[N:11]([CH3:20])[C:10]=2[N:9]=1.[CH3:21]OS(OC)(=O)=O.[OH-].[Na+]>O>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]1[N:17]([CH3:21])[C:16]2[C:15](=[O:18])[N:13]([CH3:14])[C:12](=[O:19])[N:11]([CH3:20])[C:10]=2[N:9]=1

参加物

実験手順

Beginning with 8-(5-hydroxypentylamino) theophylline in Example 3, 1.0 ml of dimethylsulfate (DMS) was added to 1.40 g of 8-(5-hydroxypentylamino) theophylline in 20 ml of water containing 0.3 g of sodiumhydroxide. The 1.0 ml DMS was added in 0.1 ml increments over of hour at: room temperature. A colorless crystalline solid separated and was collected by filtration. This solid was dried to provide 0.850 g of 8-(5-hydroxypentylamino) caffeine.