Sodium Hydroxide → 2-Cyclopentyl-2-(4-(2-quinolylmethoxy)phenyl)acetic acid

HRID 1721682ノート

反応式

HRID 1721682 の反応式
C[O:2][C:3](=[O:28])[CH:4]([CH:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1)[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=2)=[CH:7][CH:6]=1.[OH-].[Na+]>CO>[CH:23]1([CH:4]([C:5]2[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]3[CH:22]=[CH:21][C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[N:14]=3)=[CH:7][CH:6]=2)[C:3]([OH:28])=[O:2])[CH2:24][CH2:25][CH2:26][CH2:27]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 146748352-Cyclopentyl-2-(4-(2-quinolylmethoxy)phenyl)acetic acid methyl ester

生成物 1

HCID 98969182-Cyclopentyl-2-(4-(2-quinolylmethoxy)phenyl)acetic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

To a solution of the 2-cyclopentyl-2-(4-(2-quinolylmethoxy)phenyl)acetic acid methyl ester prepared in step 1 in methanol (100 ml) was added dropwise 1N sodium hydroxide (25 ml) and the resulting mixture was refluxed at 50° C. for 16 hours. The reaction mixture was then cooled to room temperature, and the methanol was removed in vacuo. The residue was acidified with 10% citric acid and the resulting solid was filtered, washed with water and dried in vacuo to provide 4.8 g of 2-cyclopentyl-2-(4-(2-quinolylmethoxy)phenyl)acetic acid.

後処理

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. customthe methanol was removed in vacuo
  3. filtrationthe resulting solid was filtered
  4. washwashed with water
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-c7abd61f625642ec98ba0a2eecca64df
出典データセット
uspto-grants-1996_04
特許番号
US05512581

反応ノート

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