Potassium Carbonate → Ethyl-2-(2-propylimidazol-1-yl)propanoate

HRID 1721885ノート

反応式

HRID 1721885 の反応式
[CH2:1]([C:4]1[NH:5][CH:6]=[CH:7][N:8]=1)[CH2:2][CH3:3].Br[CH:10]([CH3:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:14]([O:13][C:11](=[O:12])[CH:10]([N:5]1[CH:6]=[CH:7][N:8]=[C:4]1[CH2:1][CH2:2][CH3:3])[CH3:16])[CH3:15]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 79040Ethyl 2-bromopropionateHCID 1626172-Propylimidazole

生成物 1

HCID 20070368Ethyl-2-(2-propylimidazol-1-yl)propanoate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-Propylimidazole (5.5 g), ethyl 2-bromopropionate (9.95 g) and potassium carbonate (12.4 g) were stirred in refluxing acetonitrile (100 ml) for 72 hours. The suspension was allowed to cool, filtered and the solvent removed under reduced pressure, yielding the title compound as an off-white foam, 9.2 g [88%].

後処理

  1. temperatureto cool
  2. filtrationfiltered
  3. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-2bd3e86144384b45b2db53708bb5d401
出典データセット
uspto-grants-1989_08
特許番号
US04853392

反応ノート

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