Ethyl bromoacetate → HCID 14622775、化合物

HRID 1721924ノート

反応式

HRID 1721924 の反応式
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([C:9]([C:11]2[N:15]([CH2:16][O:17][CH2:18][CH3:19])[N:14]=[CH:13][CH:12]=2)=[O:10])[CH:5]=[CH:4][C:3]=1[OH:20].Br[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([C:9]([C:11]2[N:15]([CH2:16][O:17][CH2:18][CH3:19])[N:14]=[CH:13][CH:12]=2)=[O:10])[CH:5]=[CH:4][C:3]=1[O:20][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]

参加物

5

反応物 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 14622774HCID 14622774、化合物

生成物 1

HCID 14622775HCID 14622775、化合物収率 88.9%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

1.67 g of 2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenol, 1.15 g of ethyl bromoacetate and 1.68 g of potassium carbonate are added to 60 ml of acetone, and the mixture is refluxed for 1 hour. The reaction mixture is filtered and the filtrate is evaporated to remove solvent. The residue is dissolved in benzene, and the solution is treated with activated charcoal and evaporated to give an oil, which is then crystallized from isopropyl ether to give 1.89 g of ethyl [2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetate.

後処理

  1. temperaturethe mixture is refluxed for 1 hour
  2. filtrationThe reaction mixture is filtered
  3. customthe filtrate is evaporated
  4. customto remove solvent
  5. dissolutionThe residue is dissolved in benzene
  6. additionthe solution is treated with activated charcoal
  7. customevaporated
  8. customto give an oil, which
  9. customis then crystallized from isopropyl ether

出典と根拠

ORDレコード
ord-f2e4782b83334544bc4e8e6c0d8615b9
出典データセット
uspto-grants-1989_08
特許番号
US04853404

反応ノート

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