Sodium Hydroxide → [2,3-Dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetic acid

HRID 1721929ノート

反応式

HRID 1721929 の反応式
[Cl:1][C:2]1[C:14]([Cl:15])=[C:13]([C:16]([C:18]2[N:22]([CH2:23][O:24][CH2:25][CH3:26])[N:21]=[CH:20][CH:19]=2)=[O:17])[CH:12]=[CH:11][C:3]=1[O:4][CH2:5][C:6]([O:8]CC)=[O:7].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:14]([Cl:15])=[C:13]([C:16]([C:18]2[N:22]([CH2:23][O:24][CH2:25][CH3:26])[N:21]=[CH:20][CH:19]=2)=[O:17])[CH:12]=[CH:11][C:3]=1[O:4][CH2:5][C:6]([OH:8])=[O:7]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 14622775HCID 14622775、化合物

生成物 1

HCID 9864296[2,3-Dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetic acid収率 98%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

0.9 g of ethyl [2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetate is suspended in 20 ml of ethanol, and 10 ml of an aqueous 10% sodium hydroxide solution are added thereto. The mixture is stirred at room temperature for 1 hour. The reaction mixture is concentrated to remove ethanol and adjusted to pH 1-2 with 10% hydrochloric acid. The resulting crystals are collected by filtration, washed successively with water and isopropyl ether, and dried to give 0.82 g of [2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetic acid.

後処理

  1. concentrationThe reaction mixture is concentrated
  2. customto remove ethanol
  3. filtrationThe resulting crystals are collected by filtration
  4. washwashed successively with water and isopropyl ether
  5. customdried

出典と根拠

ORDレコード
ord-3af19ca8f9624dd39744d06d16bfa4b5
出典データセット
uspto-grants-1989_08
特許番号
US04853404

反応ノート

読み込み中…