Thionyl Chloride → 2,3,5,6-Tetrafluorobenzoyl Chloride

HRID 1722033ノート

反応式

HRID 1722033 の反応式
[F:1][C:2]1[C:10]([F:11])=[CH:9][C:8]([F:12])=[C:7]([F:13])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:16])=O>>[Cl:16][C:4]([C:3]1[C:2]([F:1])=[C:10]([F:11])[CH:9]=[C:8]([F:12])[C:7]=1[F:13])=[O:5]

参加物

3

反応物 2

HCID 24386Thionyl Chloride2 回HCID 5675332,3,5,6-Tetrafluorobenzoic Acid

生成物 1

HCID 27340282,3,5,6-Tetrafluorobenzoyl Chloride

実験手順

A mixture of 2,3,5,6-tetrafluorobenzoic acid (25 g) and thionyl chloride (40 cm3) was heated at the reflux temperature for 3 hours after which the excess thionyl chloride was removed by evaporation under reduced pressure to leave a residue of 1-chlorocarbonyl-2,3,5,6-tetrafluorobenzene. To this was added an excess of dry methanol and the mixture stirred for one hour at the ambient temperature. Removal of excess methanol by evaporation under reduced pressure gave methyl 2,3,5,6-tetrafluorobenzoate (19 g) as a mobile liquid.

後処理

  1. customwas removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-d2fa710f386d43c3b0960f8f8fe28e5f
出典データセット
uspto-grants-1989_08
特許番号
US04853414

反応ノート

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