Water → 3-Ethyl-2,4,5-trifluoro-nitrobenzene

HRID 1722300ノート

反応式

HRID 1722300 の反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH2:10][CH3:11].[N+:12]([O-])([O-:14])=[O:13].[K+].O>S(=O)(=O)(O)O>[CH2:10]([C:3]1[C:4]([F:9])=[C:5]([N+:12]([O-:14])=[O:13])[CH:6]=[C:7]([F:8])[C:2]=1[F:1])[CH3:11]

参加物

5

反応物 3

HCID 962WaterHCID 24434Potassium NitrateHCID 148346762,3,6-Trifluoro-1-ethylbenzene

生成物 1

HCID 148346773-Ethyl-2,4,5-trifluoro-nitrobenzene収率 81.6%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒2 回

実験手順

2,3,6-Trifluoro-1-ethylbenzene (1.09 g) is dissolved in conc. sulfuric acid (5.5 ml), and thereto is added with stirring a mixture of potassium nitrate (0.83 g) in conc. sulfuric acid (4 ml) at room temperature, and the mixture is stirred at the same temperature for one hour. The reaction mixture is poured into cold water (100 ml) and is extracted with diethyl ether. The ether layer is washed with aqueous saturated sodium chloride and dried over magnesium sulfate and then concentrated under reduced pressure to give 3-ethyl-2,4,5-trifluoro-nitrobenzene (1.14 g), as yellow oil.

後処理

  1. additionis added
  2. stirringthe mixture is stirred at the same temperature for one hour
  3. extractionis extracted with diethyl ether
  4. washThe ether layer is washed with aqueous saturated sodium chloride
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-be8369021ff946aaa140e07e2458d587
出典データセット
uspto-grants-1989_08
特許番号
US04855292

反応ノート

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