Carbonic Acid → 2-Hydroxy-2,4-dimethyl-3-pentanone

To a stirred solution of 28.3 ml. (0.2 mole) 2,4-dimethyl-3-pentanone in 100 ml. chloroform was added dropwise 10.3 ml. (0.2 mole) bromine in 30 ml. of the same solvent. The resulting mixture was stirred for a few minutes, the solvent evaporated in vacuo, the residue taken up in 100 ml. ethanol. Water, 50 ml., and 10M sodium hydroxide, 50 ml., added. The resulting mixture was stirred at reflux for one hour, diluted with 200 ml. water and extracted with 3×50 ml. ethyl ether. The extracts were dried (MgSO4) evaporated to dryness and the residue distilled to obtain 15.95 g. (61%) of the hydroxy-ketone, b.p. 60°-62° C./18 mm.

1. customthe solvent evaporated in vacuo
2. addition, added
3. stirringThe resulting mixture was stirred
4. temperatureat reflux for one hour
5. additiondiluted with 200 ml
6. extractionwater and extracted with 3×50 ml
7. dry with materialThe extracts were dried (MgSO4)
8. customevaporated to dryness
9. distillationthe residue distilled
10. customto obtain 15.95 g

ORDレコード

ord-65577de95dd549fba4bf3e09231aa0a4

出典データセット

uspto-grants-1989_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04855454