Water → 1-Bromo-5-nitroisoquinoline
反応式
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[N+:12]([O-])([O-:14])=[O:13].[K+].O.C([O-])(O)=O.[Na+]>OS(O)(=O)=O.CCOC(C)=O>[Br:1][C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1参加物
7
実験手順
The starting material was prepared by reactio of 1-bromoisoquinoline in concentrated H2SO4 at 0° with KNO3. The reaction mixture was worked up with water, NaHCO3 and EtOAc to give 1-bromo-5-nitro isoquinoline, m.p. 187°-8°. Reaction of this compound with trimethyloxonium tetrafluoroborate in CH2Cl2 gave impure 1-bromo-2-methyl-5-nitroisoquinolinium tetrafluoroborate which was used as such. n.m.r. in solvent A:-3.5(s, 3H); 7.7-8.7(m, 5H).
出典と根拠
- ORDレコード
- ord-e92c7e54245c484898568b3d1d94b3d3
- 出典データセット
- uspto-grants-1989_08
- 特許番号
- US04855420
反応ノート
読み込み中…