Formaldehyde → (2S)-2-[benzyl(methyl)amino]propanoic acid

HRID 1722618ノート

反応式

HRID 1722618 の反応式
[CH2:1]([NH:8][C@H:9]([C:11]([OH:13])=[O:12])[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]=O>C(O)=O>[CH3:14][N:8]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C@H:9]([C:11]([OH:13])=[O:12])[CH3:10]

参加物

4

反応物 2

HCID 712FormaldehydeHCID 723764N-benzyl-L-alanine

生成物 1

HCID 825998(2S)-2-[benzyl(methyl)amino]propanoic acid

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

The N-benzylalanine (1), (67 g, 0.374 mole) was taken up in formic acid (41 mL, 88%) and formaldehyde (37 mL, 38%) added. The resulting solution was heated on a steam bath for 11/2 hours. After this period the clear solution was cooled and as much of the solvent as possible removed under reduced pressure. Removal of the water was aided by co-evaporation with methanol. To the residual oil was added methanol (200 mL) and the solution diluted with ether yielding the product as a fine white powder, 63.7 g (88%).

後処理

  1. temperatureThe resulting solution was heated on a steam bath for 11/2 hours
  2. temperatureAfter this period the clear solution was cooled
  3. customas much of the solvent as possible removed under reduced pressure
  4. customRemoval of the water
  5. additionTo the residual oil was added methanol (200 mL)
  6. additionthe solution diluted with ether yielding the product as a fine white powder, 63.7 g (88%)

出典と根拠

ORDレコード
ord-19abd6cebd6646319ae21afeff832679
出典データセット
uspto-grants-1989_08
特許番号
US04857440

反応ノート

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