Phenacyl bromide → (R)-2-Bromo-1-phenylethanol
反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].ClCC(C1C=CC=CC=1)=O>>[Br:1][CH2:2][C@H:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[OH:4]参加物
3
実験手順
The procedure as in Example 3 was repeated except that 7.5 g of 2-bromo-acetophenone was employed as a substrate in place of 7.5 g of 2-chloro-acetophenone to give 4.2 g of (S)-2-bromo-1-phenyl ethanol (b.p. 85° C./0.5 mmHg). The product had a specific rotatory power [α]D25 +48.7° (C=1, chloroform) and an optical purity of 97% enantiomer excess by an HPLC analysis.
出典と根拠
- ORDレコード
- ord-9fc6f468f052462385aae0e994d36900
- 出典データセット
- uspto-grants-1989_08
- 特許番号
- US04857468
反応ノート
読み込み中…