Hydrochloric Acid → HCID 136084769、化合物
反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][C:11]([CH3:15])=[C:12]([CH3:14])[N:13]=2)=[CH:5][CH:4]=1.Cl.[OH-].[NH4+]>N1C=CC=CC=1>[CH3:14][C:12]1[N:13]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=2)[S:10][C:11]=1[CH3:15]参加物
5
実験手順
The product of part (a) (70.7 g) was added to 470 g pyridine saturated with hydrogen chloride gas, and the mixture was heated 2 hours at reflux. The reaction mixture was poured into 3000 ml ice-water, made basic with ammonium hydroxide, and the solid product was collected. The latter was purified by recrystallization from toluene to give 38.8 g 4-(4,5-dimethyl-2-thiazolyl)phenol, m.p. 194-195° C.
後処理
- temperaturethe mixture was heated 2 hours
- temperatureat reflux
- customthe solid product was collected
- customThe latter was purified by recrystallization from toluene
出典と根拠
- ORDレコード
- ord-849a669f4275470fbf1c250ed75895fc
- 出典データセット
- uspto-grants-1989_08
- 特許番号
- US04857539
反応ノート
読み込み中…