Acetyl chloride → 1-Acetyl-5-amino-3-benzylthio-1,2,4-triazole

HRID 1722930ノート

反応式

HRID 1722930 の反応式
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([S:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.C(N(CC)CC)C.[C:22](Cl)(=[O:24])[CH3:23].[OH-].[Na+]>C(Cl)Cl>[C:22]([N:6]1[C:2]([NH2:1])=[N:3][C:4]([S:7][CH2:8][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)=[N:5]1)(=[O:24])[CH3:23]

参加物

6

反応物 4

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 7372725-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine

生成物 1

HCID 142551221-Acetyl-5-amino-3-benzylthio-1,2,4-triazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To 30 g (0.145 mol) 5-amino-3-benzylthio-1H-1,2,4-triazole and 25 ml triethylamine in 300 ml methylene chloride, 12.57 g (0.16 mol) acetyl chloride in 30 ml methylene chloride was added dropwise. It was then stirred at room temperature for 30 minutes, treated with 160 ml 1N caustic soda and the product extracted with methylene chloride. After drying it was recrystallised from ethyl acetate.

後処理

  1. extractionthe product extracted with methylene chloride
  2. customAfter drying it
  3. customwas recrystallised from ethyl acetate

出典と根拠

ORDレコード
ord-750e84dd79d44b36b62808683548c0fc
出典データセット
uspto-grants-1989_08
特許番号
US04859231

反応ノート

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