Nitric Acid → 2-Ethyl-6-nitrophenol

HRID 1723001

反応式

HRID 1723001 の反応式
CCOCC.[CH2:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14])[CH3:7].[N+:15]([O-])([OH:17])=[O:16]>O>[CH2:6]([C:8]1[C:9]([OH:14])=[C:10]([N+:15]([O-:17])=[O:16])[CH:11]=[CH:12][CH:13]=1)[CH3:7]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 3283Diethyl EtherHCID 69972-Ethylphenol

生成物 1

HCID 150363132-Ethyl-6-nitrophenol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a stirred mixture of 130 ml of ether, 130 ml of water and 10.0 g of 2-ethylphenol was added dropwise 6.7 ml of 61% nitric acid, and the reaction was continued with stirring at room temperature for 4 hours. The reaction mixture was extracted with 300 ml of ethyl acetate and washed with a brine, and then dried with anhydrous sodium sulfate. The drying agent was filtered off and the solvent was distilled away under reduced pressure. The residue was purified by subjecting to silica-gel column-chromatography [eluent: chloroform]to give 5.75 g of 6-ethyl-2-nitrophenol.

後処理

  1. extractionThe reaction mixture was extracted with 300 ml of ethyl acetate
  2. washwashed with a brine
  3. dry with materialdried with anhydrous sodium sulfate
  4. filtrationThe drying agent was filtered off
  5. distillationthe solvent was distilled away under reduced pressure
  6. customThe residue was purified

出典と根拠

ORDレコード
ord-c9bd3d9f9baa4e92a762890ff4b9b9ea
出典データセット
uspto-grants-1989_08
特許番号
US04859661

関連ノート

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