Nitric Acid → 2-Nitro-4-(propan-2-yl)phenol

HRID 1723004ノート

反応式

HRID 1723004 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[N+:11]([O-])([OH:13])=[O:12]>O>[CH:8]([C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[C:3]([N+:11]([O-:13])=[O:12])[CH:4]=1)([CH3:10])[CH3:9]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 74654-Isopropylphenol

生成物 1

HCID 5289662-Nitro-4-(propan-2-yl)phenol

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

To a suspension of 5.0 g of 4-hydroxycumene in 14 ml of water was added dropwise 4.0 ml of 70% nitric acid while cooling with ice and the temperature of mixture was raised to room temperature and the reaction was carried out for 40 minutes. After 500 ml of water was added thereto, the reaction mixture was extracted with 500 ml of ethyl acetate, washed with water and a brine successively, and dried with anhydrous sodium sulfate. The drying agent was filtered off and the solvent was distilled away under reduced pressure. The residue was purified by subjecting silica-gel column-chromatography [eluent: ethyl acetate]to give 5.07 g of 4-isopropyl-2-nitrophenol.

後処理

  1. temperaturewhile cooling with ice
  2. extractionthe reaction mixture was extracted with 500 ml of ethyl acetate
  3. washwashed with water
  4. dry with materiala brine successively, and dried with anhydrous sodium sulfate
  5. filtrationThe drying agent was filtered off
  6. distillationthe solvent was distilled away under reduced pressure
  7. customThe residue was purified

出典と根拠

ORDレコード
ord-87a08d2316084763b5539baff75a31f3
出典データセット
uspto-grants-1989_08
特許番号
US04859661

反応ノート

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