Ethanolamine → HCID 20026677、化合物
反応式
[CH3:1][C:2]1O[C:4]([CH3:7])=[N:5][N:6]=1.[CH2:8]([CH2:10][NH2:11])[OH:9]>CN1CCCC1=O>[CH3:1][C:2]1[N:11]([CH2:10][CH2:8][OH:9])[C:4]([CH3:7])=[N:5][N:6]=1参加物
4
反応条件
- 温度
- 160 °C
実験手順
2,5-Dimethyl-1,3,4-oxadiazole (19.7 g, 0.2 mmole) and ethanolamine (18.3 g, 0.3 mole) were dissolved in 1-methyl-2-pyrrolidinone (20 ml) and the stirred reaction mixture heated at 160° C. for 24 hours, then cooled to ambient temperature. The residual gum was chromatographed on silica eluting with ethyl acetate containing from 20% to 50% methanol. Evaporation of the appropriate fractions and trituration of the residual foam with ethyl acetate gave the title product (14 g, 50%).
後処理
- customthe stirred reaction mixture
- temperaturecooled to ambient temperature
- customThe residual gum was chromatographed on silica eluting with ethyl acetate containing from 20% to 50% methanol
- customEvaporation of the appropriate fractions and trituration of the residual foam with ethyl acetate
出典と根拠
- ORDレコード
- ord-2732fdbb68164b65a78042d9e0a38abf
- 出典データセット
- uspto-grants-1989_08
- 特許番号
- US04859686
反応ノート
読み込み中…