Tetrahydrofuran → (2-Methyl-1H-benzimidazol-4-yl)methanol
反応式
[CH3:1][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11](OCC)=[O:12])[C:4]=2[N:3]=1.O1CCCC1.[AlH4-].[Li+].C(OCC)(=O)C>O>[CH3:1][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([CH2:11][OH:12])[C:4]=2[N:3]=1参加物
6
実験手順
(a-2) A cooled (0° C.) solution of 10 parts of ethyl 2-methyl-1H-benzimidazole-4-carboxylate in 45 parts of tetrahydrofuran was added dropwise to a suspension of 4 parts of lithium tetrahydroaluminate in 45 parts of tetrahydrofuran. Upon complete addition, the temperature was allowed to reach room temperature. After the addition of ethyl acetate and water, the reaction mixture was filtered over diatomaceous earth. The filtrate was evaporated, yielding 6.3 parts (79.4%) of 2-methyl-1H-benzimidazole-4-methanol as a residue (int. 66).
後処理
- additionUpon complete addition
- customto reach room temperature
- filtrationthe reaction mixture was filtered over diatomaceous earth
- customThe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-fdcb98520d294504a9287656ca2d82b5
- 出典データセット
- uspto-grants-1989_08
- 特許番号
- US04859684
反応ノート
読み込み中…