Methanol → (4-Amino-3-nitrophenyl)(phenyl)methanol

HRID 1723126ノート

反応式

HRID 1723126 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[CH:4][C:3]=1[N+:16]([O-:18])=[O:17].CO.[BH4-].[Na+]>O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[OH:9])=[CH:4][C:3]=1[N+:16]([O-:18])=[O:17]

参加物

5

反応物 3

HCID 887MethanolHCID 5969704-Amino-3-nitrobenzophenoneHCID 4311764Sodium borohydride

生成物 1

HCID 14518359(4-Amino-3-nitrophenyl)(phenyl)methanol

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

(a-1) To a stirred and cooled (water-bath) mixture of 48.5 parts of (4-amino-3-nitrophenyl)phenylmethanone and 320 parts of methanol were added portionwise 11.4 parts of sodium tetrahydroborate. Upon completion, stirring was continued for 15 minutes at room temperature. 100 Parts of water were added and the methanol was evaporated. The precipitated product was filtered off, washed with water, dried, filtered and crystallized twice from a moisture of methanol and water, yielding 19.6 parts of 4-amino-3-nitro-α-phenylbenzenemethanol; mp. 125° C. (int. 124).

後処理

  1. temperaturecooled
  2. stirringUpon completion, stirring
  3. customthe methanol was evaporated
  4. filtrationThe precipitated product was filtered off
  5. washwashed with water
  6. customdried
  7. filtrationfiltered
  8. customcrystallized twice from a moisture of methanol and water

出典と根拠

ORDレコード
ord-4947ff887190423fa6c9feb318dc5047
出典データセット
uspto-grants-1989_08
特許番号
US04859684

反応ノート

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