Pilocarpine → Pilocarpine Alpha Tocopherol Hemisuccinate

HRID 1723310

反応式

HRID 1723310 の反応式
[CH3:1][CH2:2][C@@H:3]1[C:7](=[O:8])[O:6][CH2:5][C@@H:4]1[CH2:9][C:10]1[N:14]([CH3:15])[CH:13]=[N:12][CH:11]=1.[CH3:16][C:17]1[C:22]([CH3:23])=[C:21]([O:24][C:25]([CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[O:26])[C:20]([CH3:32])=[C:19]2[CH2:33][CH2:34][C@:35]([CH2:38][CH2:39][CH2:40][C@@H:41]([CH2:43][CH2:44][CH2:45][C@@H:46]([CH2:48][CH2:49][CH2:50][CH:51]([CH3:53])[CH3:52])[CH3:47])[CH3:42])([CH3:37])[O:36][C:18]=12.CC1C(C)=C2C(CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2)=C(C)C=1O>C(Cl)Cl>[CH3:1][CH2:2][C@@H:3]1[C:7](=[O:8])[O:6][CH2:5][C@@H:4]1[CH2:9][C:10]1[N:14]([CH3:15])[CH:13]=[N:12][CH:11]=1.[CH3:16][C:17]1[C:22]([CH3:23])=[C:21]([O:24][C:25]([CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[O:26])[C:20]([CH3:32])=[C:19]2[CH2:33][CH2:34][C@:35]([CH2:38][CH2:39][CH2:40][C@@H:41]([CH2:43][CH2:44][CH2:45][C@@H:46]([CH2:48][CH2:49][CH2:50][CH:51]([CH3:53])[CH3:52])[CH3:47])[CH3:42])([CH3:37])[O:36][C:18]=12

参加物

5

反応物 3

HCID 5910Pilocarpine2 回HCID 14985alpha-TocopherolHCID 20353alpha-Tocopherol succinate

生成物 1

HCID 131716046Pilocarpine Alpha Tocopherol Hemisuccinate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
25 °C

実験手順

Five grams of pilocarpine base were added to a weighed 500 ml round bottom flask and stopper, and the total mass in grams recorded. D-alpha-tocopherol acid succinate (12.75 g, corresponding to a 1:1M ratio of pilocarpine:D-alpha-tocopherol) was added to the flask and the contents again weighed. Methylene chloride (50 ml) was added and the flask agitated to dissolve the solids and the flask again weighed. The flask was placed on a rotary evaporator in a water bath at 55° C. and rotated for 30 minutes (no vacuum applied). After 30 minutes, the flask and contents were again weighed, then rotary evaporated with vacuum at 55° C. The weight of the flask was recorded every 30 minutes thereafter until two successive weighings were within 0.1 g. The preparation was then cooled to room temperature (25° C.), stoppered, and stored at 4° C.

後処理

  1. dissolutionto dissolve the solids
  2. customThe flask was placed on a rotary evaporator in a water bath at 55° C.
  3. waitAfter 30 minutes
  4. customrotary evaporated with vacuum at 55° C
  5. waitThe weight of the flask was recorded every 30 minutes
  6. customstored at 4° C.

出典と根拠

ORDレコード
ord-b4f7990c8dc145e58418d4781472d9ef
出典データセット
uspto-grants-1989_08
特許番号
US04861580

関連ノート

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