Hydrochloric Acid → (E)-2-[2-(4-Pyrrolidinobutoxyphenyl)ethenyl]benzothiazole

反応式

Cl[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1/[CH:13]=[CH:14]/[C:15]1[S:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1.[NH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1.Cl>>[N:24]1([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2/[CH:13]=[CH:14]/[C:15]2[S:16][C:17]3[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=3[N:19]=2)[CH2:28][CH2:27][CH2:26][CH2:25]1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 31268Pyrrolidine

HCID 20025798HCID 20025798、化合物

生成物 1

HCID 20025806(E)-2-[2-(4-Pyrrolidinobutoxyphenyl)ethenyl]benzothiazole収率 33%

実験手順

The title compound was prepared in accordance with Example 38 starting with (H) of Example 38 (3.0 g, 8.7 mmol) and using pyrrolidine in place of dipropylamine to produce 1.1 g (33% yield) of the title compound as the HCl salt, mp 220°-222° C. IR(KBr): 3410, 1600 cm-1. MS: 379(MH+). 1H NMR (CD3OD): δ 8.02-6.91 (m, 10H), 4.12 (t, J=5.2 Hz, 2H), 3.23 (m, 6H), 2.54 (m, 4H), 2.21 (m, 4H).

出典と根拠

ORDレコード: ord-f4147da308c24eea947ad7f5f89e5597
出典データセット: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04861897

反応ノート

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