Trifluoroacetic acid → 4-(2-Chlorophenylamino)-5,6-difluoro-1,2-dihydroindazol-3-one

HRID 1723694ノート

反応式

HRID 1723694 の反応式
COC(=O)[C:4]1[C:9]([NH:10][NH:11][C:12](OC(C)(C)C)=[O:13])=[CH:8][C:7]([F:19])=[C:6]([F:20])[C:5]=1[NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[Cl:28].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[NH:21][C:5]1[C:6]([F:20])=[C:7]([F:19])[CH:8]=[C:9]2[C:4]=1[C:12](=[O:13])[NH:11][NH:10]2

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 865985976-(N'-tert-Butoxycarbonylhydrazino)-2-(2-chlorophenylamino)-3,4-difluorobenzoic acid methyl ester

生成物 1

HCID 674033074-(2-Chlorophenylamino)-5,6-difluoro-1,2-dihydroindazol-3-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

6-(N′-tert-Butoxycarbonylhydrazino)-2-(2-chlorophenylamino)-3,4-difluorobenzoic acid methyl ester (1.00 equivalent) is treated with a 1:1 mixture of methylene chloride and TFA and stirred for 2 hours The reaction mixture is concentrated under reduced pressure and the product is purified by trituration or flash column chromatography if needed.

後処理

  1. concentrationis concentrated under reduced pressure
  2. customthe product is purified by trituration or flash column chromatography

出典と根拠

ORDレコード
ord-f465b05b652b48fc9d63acece16c8913
出典データセット
uspto-grants-2009_02
特許番号
US07485643B2

反応ノート

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