2,3-Dihydroxybutanedioic Acid → HCID 729944、化合物

HRID 1723707ノート

反応式

HRID 1723707 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9](O)(=[O:17])[CH:10]([CH:12]([C:14](O)=[O:15])[OH:13])[OH:11]>C1(C)C(C)=CC=CC=1>[CH2:1]([N:8]1[C:14](=[O:15])[C@@H:12]([OH:13])[C@H:10]([OH:11])[C:9]1=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 7504Benzylamine

生成物 1

HCID 729944HCID 729944、化合物収率 77.5%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

Benzylamine (75 g, 0.70 mol) and (−)-tartaric acid (100 g, 700 mol) were heated in boiling xylene (1.0 L) in a Dean-Stark apparatus. After cooling, the product was collected, washed with acetone, and recrystallized from EtOH to afford the product (120 g, 77%). 1H NMR (300 MHz, CDCl3) δ 7.39-7.20 (5H, m), 6.27 (2H, d), 4.58 (1H, d), 4.52 (1H, d), 4.38 (2H, m).

後処理

  1. temperatureAfter cooling
  2. customthe product was collected
  3. washwashed with acetone
  4. customrecrystallized from EtOH

出典と根拠

ORDレコード
ord-31329337faf5449bb3a62378714cfb2d
出典データセット
uspto-grants-2009_02
特許番号
US07485641B2

反応ノート

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