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Tetrahydrofuran → Tert-butyl 3-[1-(3,5-difluorophenyl)-1-hydroxy-2,2-diethylpropyl]azetidine-1-carboxylate

HRID 1724210
ノート
印刷プレビュー

反応式

HRID 1724210 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:18]=[C:19]([F:21])[CH:20]=1)[C:5]([CH:7]1[CH2:10][N:9]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:8]1)=[O:6].[C:22]([Mg]Cl)(C)(C)[CH3:23].[NH4+].[Cl-].[CH2:30]1[CH2:34]O[CH2:32][CH2:31]1>>[F:1][C:2]1[CH:3]=[C:4]([C:5]([CH:7]2[CH2:10][N:9]([C:11]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:12])[CH2:8]2)([OH:6])[C:31]([CH2:22][CH3:23])([CH2:30][CH3:34])[CH3:32])[CH:18]=[C:19]([F:21])[CH:20]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

5

反応物 4

HCID 8028TetrahydrofuranHCID 25517Ammonium ChlorideHCID 670659051,1-Dimethylethyl 3-(3,5-difluorobenzoyl)-1-azetidinecarboxylateHCID 178418310HCID 178418310、化合物

生成物 1

HCID 69057678Tert-butyl 3-[1-(3,5-difluorophenyl)-1-hydroxy-2,2-diethylpropyl]azetidine-1-carboxylate

反応条件

温度
-78 °C

実験手順

To a solution of 3.07 g (10.34 mmol) of tert-butyl 3-(3,5-difluorobenzoyl)azetidine-1-carboxylate in 20 mL of THF, 36.19 mL (36.19 mmol) of tert-butyl magnesium chloride was added and stirred for 3.5 h at −78° C. To the solution was added 8 mL of aq. NH4Cl and the solution was filtered to remove the solid. The filtrate was washed with ether. The combined organic layer was concentrated to remove solvents and residue was purified by silica gel chromatography with hexanes/ethyl acetate to afford the title compound; 1H-NMR(CDCl3) δ 0.897 (s, 9H), 1.425 (s, 9H), 2.234(br, 1H), 3.25 (m, 1H), 3.55 (m, 1H), 3.71 (t, J=8.9 Hz, 1H), 3.97 (t, J=8.4 Hz, 1H), 4.17(m ,1H), 6.53-6.74 (m, 3H).

後処理

  1. filtrationthe solution was filtered
  2. customto remove the solid
  3. washThe filtrate was washed with ether
  4. concentrationThe combined organic layer was concentrated
  5. customto remove solvents and residue
  6. customwas purified by silica gel chromatography with hexanes/ethyl acetate

出典と根拠

ORDレコード
ord-bc3320d818bb4b5c9719c03e656f66c9
出典データセット
uspto-grants-2009_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07485732B2

反応ノート

読み込み中…

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