Trifluoroacetic acid → 3-[1-(3,5-Difluorophenyl)-2,2-dimethylpropylidene]azetidine

HRID 1724213ノート

反応式

HRID 1724213 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[C:14]2[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]2)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[C:6]([F:8])[CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([C:9](=[C:14]2[CH2:15][NH:16][CH2:17]2)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[C:6]([F:8])[CH:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67065934Tert-butyl 3-[1-(3,5-difluorophenyl)-2,2-dimethylpropylidene]azetidine-1-carboxylate

生成物 1

HCID 670658933-[1-(3,5-Difluorophenyl)-2,2-dimethylpropylidene]azetidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 210 mg (0.623 mmol) of tert-butyl 3-[1-(3,5-difluorophenyl)-2,2-dimethylpropylidene]azetidine-1-carboxylate in 1 mL of CH2Cl2, was added 1.5 mL of TFA followed by stirring for 1 h at rt. The reaction mixture was concentrated and washed with ether to afford the title compound as white solid; Mass Spectrum: m/e=238 (M+1).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. washwashed with ether

出典と根拠

ORDレコード
ord-f5e0f3ab39d64f6584f796e3530b4cca
出典データセット
uspto-grants-2009_02
特許番号
US07485732B2

反応ノート

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