Trifluoroacetic acid → 3-[1-(3,5-Difluorophenyl)-2,2-dimethylpropyl]azetidine
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([CH:14]2[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]2)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[C:6]([F:8])[CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:9]([CH:14]2[CH2:15][NH:16][CH2:17]2)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[C:6]([F:8])[CH:7]=1参加物
4
実験手順
To a solution of 360 mg (1.06 mmol) of tert-butyl 3-[1-(3,5-difluorophenyl)-2,2-dimethylpropyl]azetidine-1-carboxylate in 1.5 mL of CH2Cl2, was added 1.5 mL of TFA and the solution was stirred for 1 h at rt. It was concentrated and washed with ether to afford the title compound as a white solid; Mass Spectrum: m/e=240 (M+1).
後処理
- concentrationIt was concentrated
- washwashed with ether
出典と根拠
- ORDレコード
- ord-9e83449c0d6f4075b87691d1dfd019d2
- 出典データセット
- uspto-grants-2009_02
- 特許番号
- US07485732B2
反応ノート
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