反応式
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:18]3[C:19]([NH2:23])=[N:20][CH:21]=[CH:22][C:17]=3[O:16][N:15]=2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:24]N1C(=O)CCC1=O>CN(C)C=O>[I:24][C:22]1[C:17]2[O:16][N:15]=[C:14]([C:11]3[CH:10]=[CH:9][C:8]([O:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)=[CH:13][CH:12]=3)[C:18]=2[C:19]([NH2:23])=[N:20][CH:21]=1参加物
4
実験手順
3-(4-Phenoxyphenyl)isoxazolo[4,5-c]pyridin-4-amine (0. 11 g, 0.36 mmol) and N-iodosuccinimide (0.098 g, 0.43 mmol) in N,N-dimethylformamide (1.5 mL) was stirred at ambient temperature for 30 minutes. The mixture was applied to a silica gel column and eluted with dichloromethane/ethyl acetate (8:2) to provide the title compound (100 mg): 1H NMR (DMSO-d6, 400 MHz) δ 8.26 (s, 1H), 7.71 (d, 2H), 7.46 (t, 2H), 7.15-7.25 (m, 5H), 6.45 (bs, 2H);
後処理
- washeluted with dichloromethane/ethyl acetate (8:2)
出典と根拠
- ORDレコード
- ord-cd43e71718b44059885bbe215a8aebbe
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07737160B2
関連ノート
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