[1-(Cyclopropylcarbamoylhydroxymethyl)cyclopropyl]carbamic acid tert-butyl ester → 2-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide

HRID 1725195

反応式

C(OC(=O)[NH:7][C:8]1([CH:11]([C:13](=[O:18])[NH:14][CH:15]2[CH2:17][CH2:16]2)[OH:12])[CH2:10][CH2:9]1)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:7][C:8]1([CH:11]([OH:12])[C:13]([NH:14][CH:15]2[CH2:16][CH2:17]2)=[O:18])[CH2:10][CH2:9]1

参加物

実験手順

A solution of [1-(cyclopropylcarbamoylhydroxymethyl)cyclopropyl]carbamic acid tert-butyl ester in CH2Cl2 (5 mL) and TFA (5 mL) was stirred at room temperature for 2.5 h. The reaction mixture was concentrated and chased with toluene to yield 2-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide.

後処理

concentrationThe reaction mixture was concentrated

出典と根拠

ORDレコード: ord-383fcd2de2b64a1182f52250e8ef12e0
出典データセット: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07488848B2

反応式

参加物

反応物 1

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

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