6-ethyl-3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one → HCID 68487141、化合物
反応式
[CH2:1]([N:3]1[C:8](=[O:9])[C:7]2=[N:10][O:11][C:12]([CH3:13])=[C:6]2[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4]1)[CH3:2]>[Pd].C(O)C>[C:12]([C:6]1[C:5]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[N:4][N:3]([CH2:1][CH3:2])[C:8](=[O:9])[C:7]=1[NH2:10])(=[O:11])[CH3:13]参加物
4
実験手順
A mixture of 6-ethyl-3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one (Dal Piaz, V et al, J. Med. Chem. 1997, 40, 1417) (2.0 g, 7.83 mmol) and 10% palladium on charcoal (400 mg) in ethanol (400 ml) was shaken under hydrogen at room temperature and 2 bar for 3 h. The catalyst was filtered off and the solvent was removed under reduced pressure to yield the title compound (1.97 g, 98% yield).
後処理
- filtrationThe catalyst was filtered off
- customthe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-bdbd59cbe678453f946f6e0782dd6375
- 出典データセット
- uspto-grants-2009_02
- 特許番号
- US07491722B2
反応ノート
読み込み中…