Water → Methyl 5-nitroquinoline-8-carboxylate

HRID 1725518

反応式

HRID 1725518 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2)([O-:3])=[O:2].IC.[C:19](=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH3:19][O:15][C:14]([C:11]1[CH:12]=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[C:5]2[C:10]=1[N:9]=[CH:8][CH:7]=[CH:6]2)=[O:16]

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 154053315-Nitroquinoline-8-carboxylic acid

生成物 1

HCID 68521805Methyl 5-nitroquinoline-8-carboxylate収率 78.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of 300 mg (1.375 mmol) of 5-nitroquinoline-8-carboxilic acid (Breckenridge, J. G. Et al., Canadian J. of Research Sect. B; 1947, 25, 49) in DMF (6 mL), 546 mg (3.850 mmol) of iodomethane and 190 mg (1.375 mmol) of potassium carbonate were added. The resulting mixture was stirred at room temperature for one hour. Water (10 mL) was added and the product collected by filtration. The residue was washed with water and dried to yield the title compound (250 mg, 78.4%).

後処理

  1. filtrationthe product collected by filtration
  2. washThe residue was washed with water
  3. customdried

出典と根拠

ORDレコード
ord-5ee214cf2dbe45b78e8225f89264efb3
出典データセット
uspto-grants-2009_02
特許番号
US07491722B2

関連ノート

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