Benzenesulfonyl chloride → Methyl 6-[(phenylsulfonyl)amino]-5-quinolinecarboxylate
反応式
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][CH:6]=[CH:5][C:4]=2[C:3]=1[C:12]([O:14][CH3:15])=[O:13].[C:16]1([S:22](Cl)(=[O:24])=[O:23])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>N1C=CC=CC=1>[C:16]1([S:22]([NH:1][C:2]2[CH:11]=[CH:10][C:9]3[N:8]=[CH:7][CH:6]=[CH:5][C:4]=3[C:3]=2[C:12]([O:14][CH3:15])=[O:13])(=[O:24])=[O:23])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1参加物
4
実験手順
A solution of Example 96B (0.233 g, 1.20 mmol) in pyridine (4 mL) was treated with benzenesulfonyl chloride (0.20 mL, 1.6 mmol), and stirred for 7 hours at ambient temperature. The mixture was concentrated and the residue was purified by C18 reverse-phase HPLC with acetonitrile/water/0.5 mM ammonium acetate to provide the desired product. MS (ESI(+)) m/e 343 (M+H)+.