Carbamimidic acid, methyl ester, hydrochloride (1:1) → 2-Methoxy-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine

HRID 1726360ノート

反応式

HRID 1726360 の反応式
[Na].[CH2:2]([C:9]1[O:10][C:11](=O)[C:12](=[CH:14][OH:15])[N:13]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl.[CH3:18][O:19][C:20](=[NH:22])[NH2:21]>C(#N)C>[CH3:18][O:19][C:20]1[NH:22][C:14](=[O:15])[C:12]([NH:13][C:9](=[O:10])[CH2:2][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)=[CH:11][N:21]=1

参加物

4

反応物 2

HCID 3083899Carbamimidic acid, methyl ester, hydrochloride (1:1)HCID 178519094HCID 178519094、化合物

生成物 1

HCID 114595982-Methoxy-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine収率 82%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
80 °C

実験手順

Acetonitrile (15 ml) was added to 2-benzyl-4-hydroxymethylene-5-oxazolone sodium salt (1.00 g, 4.44 mmol) and O-methylisourea hydrochloride (0.49 g, 4.44 mmol), and the mixture was stirred overnight at 80° C. The mixture was concentrated under reduced pressure, water (5 ml) was added, and the mixture was stirred at room temperature for 1 hour. Then, the precipitate was collected by filtration and vacuum dried to give 2-methoxy-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine (0.94 g, 3.64 mmol).

後処理

  1. concentrationThe mixture was concentrated under reduced pressure, water (5 ml)
  2. additionwas added
  3. stirringthe mixture was stirred at room temperature for 1 hour
  4. filtrationThen, the precipitate was collected by filtration and vacuum
  5. customdried

出典と根拠

ORDレコード
ord-fdffd7be3df54efeb2a8c39a896357f3
出典データセット
uspto-grants-2009_02
特許番号
US07491822B2

反応ノート

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