Acetonitrile → 2-Phenyl-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine

HRID 1726363ノート

反応式

HRID 1726363 の反応式
C(#N)C.[Na].[CH2:5]([C:12]1[O:13][C:14](=O)[C:15](=[CH:17][OH:18])[N:16]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.Cl.[C:21]([NH2:29])(=[NH:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>O>[C:22]1([C:21]2[NH:29][C:17](=[O:18])[C:15]([NH:16][C:12](=[O:13])[CH2:5][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=3)=[CH:14][N:28]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 80289Benzamidine, hydrochlorideHCID 178519094HCID 178519094、化合物

生成物 1

HCID 116524352-Phenyl-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine収率 75.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

Acetonitrile (6 ml) was added to 2-benzyl-4-hydroxymethylene-5-oxazolone sodium salt (0.50 g, 2.22 mmol) and benzamidine hydrochloride (0.35 g, 2.22 mmol), and the mixture was stirred overnight at 80° C. Water (3 ml) was added, and the mixture was stirred. The precipitate was collected by filtration, and the obtained crystals were washed with water and vacuum dried to give 2-phenyl-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine (0.51 g, 1.67 mmol).

後処理

  1. stirringthe mixture was stirred
  2. filtrationThe precipitate was collected by filtration
  3. washthe obtained crystals were washed with water and vacuum
  4. customdried

出典と根拠

ORDレコード
ord-ae925aba04ee43d7acd4cca4028f6894
出典データセット
uspto-grants-2009_02
特許番号
US07491822B2

反応ノート

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