2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde → [Rac]-1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol

HRID 1726969ノート

反応式

HRID 1726969 の反応式
[CH3:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)[N:3]=1.[CH3:20][Mg]Cl>C1COCC1>[CH3:1][C:2]1[C:7]([CH:8]([OH:9])[CH3:20])=[CH:6][CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:17])([F:19])[F:18])=[CH:12][CH:11]=2)[N:3]=1

参加物

4

反応物 2

HCID 219359652-Methyl-6-(4-trifluoromethyl-phenyl)-pyridine-3-carbaldehydeHCID 178418332HCID 178418332、化合物

生成物 1

HCID 69035957[Rac]-1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

0.470 g (1.77 mmol) of the above prepared 2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde was dissolved in 9 ml of abs. THF and treated at −10° C. with 0.89 ml of 3M methyl magnesium chloride solution (in THF). After 15 Min., the reaction mixture was carefully poured onto crashed ice/NH4Cl, extracted twice with AcOEt, washed with water and brine, dried over sodium sulfate, and evaporated to dryness to leave 0.508 g of the title product, pure according to NMR.

後処理

  1. dissolutionwas dissolved in 9 ml of abs
  2. addition, the reaction mixture was carefully poured
  3. extractionextracted twice with AcOEt
  4. washwashed with water and brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated to dryness

出典と根拠

ORDレコード
ord-caacd75d1fc54eb8b0222727b40b0d14
出典データセット
uspto-grants-2009_02
特許番号
US07495001B2

反応ノート

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