HCID 85844986、化合物 → HCID 67211384、化合物

HRID 1727250ノート

反応式

HRID 1727250 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[NH:11][C:12]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[S:13]>[OH-].[Na+].[Fe-3](C#N)(C#N)(C#N)(C#N)(C#N)C#N.[K+].[K+].[K+]>[CH:14]1([C:12]2[S:13][C:5]3[C:6]([O:9][CH3:10])=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[C:4]=3[N:11]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

参加物

4

反応物 1

HCID 85844986HCID 85844986、化合物

生成物 1

HCID 67211384HCID 67211384、化合物収率 88.1%

試薬・触媒・溶媒 2

HCID 178511488HCID 178511488、化合物触媒HCID 14798Sodium Hydroxide溶媒

反応条件

温度
0 °C

実験手順

1.26 g (4.50 mmol) of N-(2,5-dimethoxyphenyl)cyclohexanecarbothioamide is dissolved in 100 ml of a 1.5 M sodium hydroxide solution (100 ml) and the reaction medium is cooled down to 0° C. before adding 25 ml of a freshly prepared 20% aqueous solution of potassium ferricyanide (5.05 g of K3[Fe(CN)6]; 3.4 eq.). The reaction mixture is maintained under stirring at ambient temperature for 24 hours, then 1.1 g (yield=88%) of the expected benzothiazole derivative is obtained by filtration, washing with cold water and drying under reduced pressure in the presence of P2O5.

後処理

  1. temperatureThe reaction mixture is maintained

出典と根拠

ORDレコード
ord-8e467b1880694c60ab2b9bfc8d10eef9
出典データセット
uspto-grants-2009_02
特許番号
US07495021B2

反応ノート

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