Hydrochloric Acid → 4-PHENYL-1-PIPERAZINECARBOTHIOAMIDE

HRID 1727349ノート

反応式

HRID 1727349 の反応式
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:13]([NH:15]C(=O)OCC)=[S:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[OH-].[Na+]>>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([C:13](=[S:14])[NH2:15])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 1518349ETHYL (4-PHENYL-1-PIPERAZINYL)CARBOTHIOYLCARBAMATE

生成物 1

HCID 20517984-PHENYL-1-PIPERAZINECARBOTHIOAMIDE収率 63%

反応条件

温度
80 °C

実験手順

Ethyl (4-phenyl-1-piperazinyl)carbothioylcarbamate (13 g, 44 mmol) was added to conc. hydrochloric acid (44 mL), and the mixture was stirred for 2 hours at 80° C. The reaction mixture was made basic with an 8N-aqueous sodium hydroxide solution, and the crystal was collected by filtration. The crystal was washed with water, and dried to obtain a title compound (6.1 g, yield 63%).

後処理

  1. filtrationthe crystal was collected by filtration
  2. washThe crystal was washed with water
  3. customdried

出典と根拠

ORDレコード
ord-6737a75bd98743d19c6000d9c30aa9e9
出典データセット
uspto-grants-2009_02
特許番号
US07495018B2

反応ノート

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