Sodium Hydroxide → Ropivacaine

HRID 1727380ノート

反応式

HRID 1727380 の反応式
[CH3:1][CH2:2][CH2:3][N:4]1[C@H:9]([C:10]([NH:12][C:13]2[C:14]([CH3:20])=[CH:15][CH:16]=[CH:17][C:18]=2[CH3:19])=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5]1.C(C(C(C([O-])=O)O)O)([O-])=O.[OH-].[Na+]>O>[CH3:1][CH2:2][CH2:3][N:4]1[C@H:9]([C:10]([NH:12][C:13]2[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:20])=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86594745Ropivacaine tartrate

生成物 1

HCID 175805Ropivacaine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Under stirring, 126 g of ropivacaine tartrate were dissolved in 200 ml of water. To the resulting solution was added a solution of sodium hydroxide 1N, adjusting the pH of the solution around 10. During the addition of the alkaline solution, occurs the precipitation of raw base ropivacaine. The solid is filtered, washed in about 100 ml of distilled water and taken to the stove for drying. MP=142°-145° C., m=70 g (η=85.9%), [α]D25=−74.6° (c=2, MeOH).

後処理

  1. additionDuring the addition of the alkaline solution
  2. customthe precipitation of raw base ropivacaine
  3. filtrationThe solid is filtered
  4. washwashed in about 100 ml of distilled water
  5. customfor drying

出典と根拠

ORDレコード
ord-e83da9cca65c475bb40009238be5a5fe
出典データセット
uspto-grants-2009_02
特許番号
US07495105B2

反応ノート

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