Acetic Acid → 2,3-Difluoro-6-(2-methoxyethoxy)benzaldehyde
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])=[CH:4][C:3]=1[F:13].C(NC(C)C)(C)C.[Li].CN(C)[CH:24]=[O:25].C(O)(=O)C>O1CCCC1.O>[F:13][C:3]1[C:2]([F:1])=[CH:7][CH:6]=[C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])[C:4]=1[CH:24]=[O:25]参加物
7
実験手順
In a manner similar to the method described in example 52a, 1,2-difluoro-4-(2-methoxy-ethoxy)-benzene (6.3 g, 33.4 mmol) prepared in example 101a was reacted with lithium diisopropylamine (20.1 mL, 2.0 M in THF, 40.1 mmol), N,N-dimethyl-formamide (3.11 mL, 40.1 mmol) and quenched with acetic acid (8.1 g, 134 mmol) and water (41.2 mL) in tetrahydrofuran to give 2,3-difluoro-6-(2-methoxy-ethoxy)-benzaldehyde as yellow oil (Yield: 5.8 g, 80.6%).
出典と根拠
- ORDレコード
- ord-be89e56bb3634ea9b3e19aee7d471dc9
- 出典データセット
- uspto-grants-2009_02
- 特許番号
- US07495007B2
反応ノート
読み込み中…