Allyl bromide → HCID 19017731、化合物

反応式

[NH2:1][C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:5]([CH3:12])[S:4][N:3]=1.[CH2:13](Br)[CH:14]=[CH2:15]>>[CH3:12][C:5]1[S:4][N:3]=[C:2]([NH:1][CH2:13][CH2:14][CH3:15])[C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]

参加物

反応物 2

HCID 7841Allyl bromide

HCID 1901774620943-41-3

生成物 1

HCID 19017731HCID 19017731、化合物

実験手順

Ethyl 3-amino-5-methylisothiazole-4-carboxylate, prepared by the method of Hartke and Peshkar, Arch. Pharm.- Weinheim, 301(8), 611 (1968), is reacted with allyl bromide using the conditions described in Example 15A. This product is then hydrogenated using the procedure described in Example 15B to give ethyl 5-methyl-3-propylaminoisothiazole-4-carboxylate.

出典と根拠

ORDレコード: ord-bb74a833908f4381943e7b75715c1705
出典データセット: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05326776

反応ノート

読み込み中…