Dimethylformamide → Ethyl 2-(2-cyanoanilino)acetate
反応式
[C:1]([NH2:10])(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20].CN(C)C=O>O>[CH2:22]([O:21][C:19](=[O:20])[CH2:18][NH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]#[N:10])[CH3:23]参加物
6
実験手順
A mixture of anthranilamide (11.8 g), potassium carbonate (20 g), ethyl bromoacetate (18 g) and dimethylformamide (50 mL) was heated at reflux for 40 min. The reaction mixture was diluted with water and the product was extracted with ether. The organic layer was washed with water and brine, dried over magnesium sulfate and the solvent was removed in vacuo. The residue was recrystallized from ethanol to afford N-(2-Cyanophenyl)glycine ethyl ester as a colorless solid.
後処理
- temperaturewas heated
- temperatureat reflux for 40 min
- extractionthe product was extracted with ether
- washThe organic layer was washed with water and brine
- dry with materialdried over magnesium sulfate
- customthe solvent was removed in vacuo
- customThe residue was recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-98bc41b188784cc3baca6075de8ed82d
- 出典データセット
- uspto-grants-1994_07
- 特許番号
- US05326868
反応ノート
読み込み中…