1,1,1-Trifluorooctan-2-YL 6-hydroxynaphthalene-2-carboxylate → Benzoic acid, 4-((1-oxodecyl)oxy)-

HRID 1728527ノート

反応式

HRID 1728527 の反応式
OC1C=C2C(=CC=1)C=C(C(OC(CCCCCC)C(F)(F)F)=O)C=C2.FC1C=C(O)C=CC=1C(OC(CCCCCC)C(F)(F)F)=O.C(O[C:57]1[CH:62]=C[C:60]([C:63]2C=C[C:66]([C:69]([O:71][C:72]3[CH:77]=[CH:76][C:75]([C:78]([O:80]C(CCCCCC)C(F)(F)F)=[O:79])=[C:74](F)[CH:73]=3)=[O:70])=[CH:65][CH:64]=2)=[CH:59][CH:58]=1)CCCCCCC>O1CCCC1>[CH2:66]([C:69]([O:71][C:72]1[CH:77]=[CH:76][C:75]([C:78]([OH:80])=[O:79])=[CH:74][CH:73]=1)=[O:70])[CH2:65][CH2:64][CH2:63][CH2:60][CH2:59][CH2:58][CH2:57][CH3:62]

参加物

5

反応物 3

HCID 157248111,1,1-Trifluorooctan-2-YL 6-hydroxynaphthalene-2-carboxylateHCID 199208191,1,1-Trifluorooctan-2-YL 2-fluoro-4-hydroxybenzoateHCID 537499373-Fluoro-4-(1,1,1-trifluoro-2-octyloxycarbonyl)phenyl 4-octyloxybiphenyl-4'-carboxylate

生成物 1

HCID 3608562Benzoic acid, 4-((1-oxodecyl)oxy)-

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of the 1,1,1-trifluoro-2-octyl 6-hydroxynaphthalene-2-carboxylate (0.6 g) obtained in (1) above and the 4-n-nonylcarbonyloxybenzoic acid (0.45 g) obtained in (2) above in tetrahydrofuran (40 ml) were added dicyclohexylcarbodiimide (0.45 g) and dimethylaminopyridine (0.05 g). The solution was stirred overnight and distilled to remove the solvent. The residue was dissolved in dichloromethane (40 ml) and washed with dilute aqueous hydrochloric acid solution and water, in this order. The solution was dried over anhydrous magnesium sulfate and distilled to remove the solvent. The residue was purified by silica-gel column chromatography (developer: hexane/ethyl acetate=20/1) to obtain the titled compound (0.05 g) having specific rotation, [α]D20 =+42.86°.

出典と根拠

ORDレコード
ord-bf0e1b7dd9604ca29b4be6f68913986c
出典データセット
uspto-grants-1994_07
特許番号
US05328641

反応ノート

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