Thionyl Chloride → 4-(Chloromethyl)quinoline--hydrogen chloride (1/1)
反応式
Br.O[CH2:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[CH:6][CH:5]=1.S(Cl)([Cl:16])=O>>[ClH:16].[Cl:16][CH2:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[CH:6][CH:5]=1参加物
3
実験手順
A reaction mixture of 4-(hydroxymethyl)-quinoline hydrobromide (2.0 g, 12.6mmol) and thionylchloride (20 mL) was heated to reflux for 2 hours. This was allowed to cool and then concentrated in vacuum. The green solid was treated with ethyl ether, filtered, washed with ethyl ether and dried in vacuum to yield 4-(chloromethyl)-quinoline hydrochloride (2.17 g, 80.7%).
後処理
- temperaturewas heated
- temperatureto reflux for 2 hours
- temperatureto cool
- concentrationconcentrated in vacuum
- additionThe green solid was treated with ethyl ether
- filtrationfiltered
- washwashed with ethyl ether
- customdried in vacuum
出典と根拠
- ORDレコード
- ord-9b6a0e8d643b48079adb7a744577a24d
- 出典データセット
- uspto-grants-1994_07
- 特許番号
- US05331006
反応ノート
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