Tetrahydrofuran → 7-Bromo-6-iodo-8-methoxy-5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

HRID 17291ノート

反応式

HRID 17291 の反応式
[NH2:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([Br:13])[C:8]([I:14])=[C:7]([CH3:15])[C:3]=1[C:4]([OH:6])=[O:5].[O:16]1CCC[CH2:17]1>>[Br:13][C:9]1[C:8]([I:14])=[C:7]([CH3:15])[C:3]2[C:4](=[O:6])[O:5][C:17](=[O:16])[NH:1][C:2]=2[C:10]=1[O:11][CH3:12]

参加物

3

反応物 2

HCID 8028TetrahydrofuranHCID 860974752-Amino-4-bromo-5-iodo-3-methoxy-6-methylbenzoic Acid

生成物 1

HCID 866308077-Bromo-6-iodo-8-methoxy-5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

反応条件

温度
40 °C

実験手順

According to the same method as in Reference Example 31, 2-amino-4-bromo-5-iodo-3-methoxy-6-methylbenzoic acid (I-4) (3.42 g, 8.86 mmol) and bis(trichloromethyl) carbamate (893 mg, 3.01 mmol) were dissolved in dewatered tetrahydrofuran (70 ml) under nitrogen atmosphere, followed by stirring at 40° C. for 1 hour. The reaction liquid was concentrated under reduced pressure to obtain the entitled compound (3.89 g, quant.) as a pale brown solid. Not further purified, this was used in the next reaction.

後処理

  1. customThe reaction liquid
  2. concentrationwas concentrated under reduced pressure
  3. customto obtain the entitled compound (3.89 g, quant.) as a pale brown solid
  4. customNot further purified
  5. customthis was used in the next reaction

出典と根拠

ORDレコード
ord-e6864ecd40904878b728d64c6b38f328
出典データセット
uspto-grants-2010_06
特許番号
US07737166B2

反応ノート

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