Phosphate → HCID 14549129、化合物

HRID 1729139ノート

反応式

HRID 1729139 の反応式
C([O:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:20])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)[CH3:6])(=O)C.P([O-])([O-])([O-])=O>C(Cl)(Cl)Cl>[OH:4][CH:5]([C:7]1[CH:8]=[CH:9][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:20])=[CH:15][CH:14]=2)=[CH:11][CH:12]=1)[CH3:6]

参加物

4

反応物 2

HCID 1061PhosphateHCID 14534380HCID 14534380、化合物

生成物 1

HCID 14549129HCID 14549129、化合物収率 39.9%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

29.9 g (0.08 mol) of IV-15 was mixed with 800 ml of 0.1M phosphate buffer (pH 7.5), 30 ml of chloroform and 6 g of Amano Lipase P and the mixture was stirred vigorously at 30°-35° C. for 20 hours. The reaction mixture was extracted with 600 ml of methyl isobutyl ketone. The organic layer was concentrated under reduced pressure and the residue was purified by column chromatography using a 12:1 mixed solution of chloroform and ethyl acetate as eluting solvent to obtain 10.6 g of (+)-benzyl 4'-(1-hydroxyethyl)-4-biphenylcarboxylate (V-15). [α]D25 =+23.7° (c=1, CHCl3), m.p.=104°-106° C.

後処理

  1. extractionThe reaction mixture was extracted with 600 ml of methyl isobutyl ketone
  2. concentrationThe organic layer was concentrated under reduced pressure
  3. customthe residue was purified by column chromatography
  4. washas eluting solvent

出典と根拠

ORDレコード
ord-89c349c280724e6881bc36f189d09632
出典データセット
uspto-grants-1994_07
特許番号
US05332675

反応ノート

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