Ethyl 3-oxo-4-phenylbutanoate → 2,6-dibenzyl-1H-pyrimidin-4-one

HRID 1729236

反応式

HRID 1729236 の反応式
[Na].Cl.[C:3]1([CH2:9][C:10]([NH2:12])=[NH:11])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:13]1([CH2:19][C:20](=O)[CH2:21][C:22](OCC)=[O:23])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C>[C:3]1([CH2:9][C:10]2[N:12]=[C:20]([CH2:19][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:21]=[C:22]([OH:23])[N:11]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 225855Ethyl 3-oxo-4-phenylbutanoateHCID 5360545SodiumHCID 124155142-Phenylethanimidamide hydrochloride

生成物 1

HCID 1785158572,6-dibenzyl-1H-pyrimidin-4-one収率 34.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of sodium (1.84 g, 80 mmol) in ethanol (200 ml) was added phenylacetamidine hydrochloride (16.2 g, 95.0 mmol) and ethyl 4-phenylacetoacetate (15 g, 72.9 mmol). The mixture was heated under reflux with stirring for 5 days followed by cooling and evaporation in vacuo. Water (150 ml) was added to the residue causing a solid to precipitate which was filtered off and washed thoroughly with water and diethyl ether. Recrystallisation of the solid from a chloroform/hexane mixture afforded 6.9 g 2,4-di(phenylmethyl)-6-hydroxypyrimidine as a white solid. m.pt., 158°-160° C., M+ found: 276.

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux
  3. temperatureby cooling
  4. customevaporation in vacuo
  5. additionWater (150 ml) was added to the residue
  6. customto precipitate which
  7. filtrationwas filtered off
  8. washwashed thoroughly with water and diethyl ether
  9. customRecrystallisation of the solid from a chloroform/hexane mixture

出典と根拠

ORDレコード
ord-82d63ebf3c5048e2a9da1de12a330986
出典データセット
uspto-grants-1994_07
特許番号
US05332745

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