Hydroxyamine hydrochloride → HCID 136378409、化合物

反応式

[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]([C:8]1[CH:13]=[CH:12][C:11]([S:14][C:15]2[CH:20]=[C:19]([F:21])[CH:18]=[C:17]([C:22]3([O:28][CH3:29])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[CH:16]=2)=[CH:10][CH:9]=1)=O.Cl.[NH2:31][OH:32]>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6](=[N:31][OH:32])[C:8]1[CH:13]=[CH:12][C:11]([S:14][C:15]2[CH:20]=[C:19]([F:21])[CH:18]=[C:17]([C:22]3([O:28][CH3:29])[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[CH:16]=2)=[CH:10][CH:9]=1

参加物

反応物 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996235HCID 18996235、化合物

生成物 1

HCID 136378409HCID 136378409、化合物収率 40%

実験手順

Using an analogous procedure to that described in Example 12, 4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]phenyl 2-thiazolyl ketone was reacted with hydroxylamine hydrochloride to give in turn the geometric isomers of 4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]phenyl 2-thiazolyl ketone oxime:Isomer A in 40% yield, m.p. 153°-154° C.,

出典と根拠

ORDレコード: ord-be629c27c54e4e669109022b4b4847fa
出典データセット: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05332757

反応ノート

読み込み中…

参加物