Sodium Hydroxide → 7-[Cyano(4-hydroxynonyl)amino]-2-methylheptanoic acid

HRID 1729917ノート

反応式

HRID 1729917 の反応式
C([O:4][CH:5]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:6][CH2:7][CH2:8][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([CH3:23])[C:18]([O:20]CC)=[O:19])[C:10]#[N:11])(=O)C.[OH-].[Na+]>C(O)C.O>[OH:4][CH:5]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:6][CH2:7][CH2:8][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([CH3:23])[C:18]([OH:20])=[O:19])[C:10]#[N:11]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 86734144HCID 86734144、化合物

生成物 1

HCID 714447117-[Cyano(4-hydroxynonyl)amino]-2-methylheptanoic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of ethyl 7-[N-(4-acetoxynonyl)cyanamido] -2-methylheptanoate (7.6 g., 0.02 mole) in ethanol (50 ml.) is added a solution of sodium hydroxide (1.6 g., 0.04 mole) in water (15 ml.) and the reaction is stirred at ambient temperature for 20 hours. Then most of the ethanol is removed in vacuo and the residue taken up in water (150 ml.). The solution is extracted once with ether then acidified with hydrochloric acid (dil.). The oil that separates is extracted into ether, the ether is washed with brine, dried over sodium sulfate, then removed under vacuum to give 7-[N-(4-hydroxynonyl)cyanamido]-2-methylheptanoic acid as a yellow oil.

後処理

  1. customThen most of the ethanol is removed in vacuo
  2. extractionThe solution is extracted once with ether
  3. extractionThe oil that separates is extracted into ether
  4. washthe ether is washed with brine
  5. dry with materialdried over sodium sulfate
  6. customremoved under vacuum

出典と根拠

ORDレコード
ord-74acb03a106e417b970cefe90ee5e55b
出典データセット
uspto-grants-1976_11
特許番号
US03989749

反応ノート

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