Imidazole → 1-[N-2-chlorophenyl-N-propyl (thiocarbamoyl)]imidazole

HRID 1730027ノート

反応式

HRID 1730027 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:12][CH2:13][CH3:14])[C:9](Cl)=[S:10].[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:12][CH2:13][CH3:14])[C:9]([N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)=[S:10]

参加物

4

反応物 2

HCID 795Imidazole2 回HCID 21319512Carbamothioic chloride, (2-chlorophenyl)propyl-

生成物 1

HCID 542482291-[N-2-chlorophenyl-N-propyl (thiocarbamoyl)]imidazole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

12.4 g. N-2-chlorophenyl-N-propyl(thiocarbamoyl) chloride and 6.8 g. imidazole were refluxed in 75 ml. dry tetrahydrofuran for 16 hours. A further 2 g. imidazole was then added and the heating continued for 8 hours. After separating the solid formed evaporation of the tetrahydrofuran left an oil which was dissolved in methylene chloride. The resulting organic phase was washed with water, dried with soldium sulphate and the solvent evaporated to leave an oil which crystallised on treatment with light petroleum and chilling to give the product, 1-[N-2-chlorophenyl-N-propyl (thiocarbamoyl)]imidazole, m.p. 59°-61° C.

後処理

  1. customAfter separating the solid
  2. customformed
  3. customevaporation of the tetrahydrofuran
  4. waitleft an oil which
  5. dissolutionwas dissolved in methylene chloride
  6. washThe resulting organic phase was washed with water
  7. dry with materialdried with soldium sulphate
  8. customthe solvent evaporated
  9. customto leave an oil which
  10. customcrystallised on treatment with light petroleum
  11. temperaturechilling

出典と根拠

ORDレコード
ord-78dcce6112dc4e2aaeb2b09ec17d2b79
出典データセット
uspto-grants-1976_11
特許番号
US03991071

反応ノート

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