Acetic Acid → 4-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

HRID 17301ノート

反応式

HRID 17301 の反応式
[I:1]N1C(=O)CCC1=O.C(O)(=O)C.[Br:13][C:14]1[C:20]([CH3:21])=[CH:19][C:17]([NH2:18])=[C:16]([O:22][CH3:23])[C:15]=1[F:24]>[Cl-].[Na+].O>[Br:13][C:14]1[C:20]([CH3:21])=[C:19]([I:1])[C:17]([NH2:18])=[C:16]([O:22][CH3:23])[C:15]=1[F:24]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 120273N-IodosuccinimideHCID 860974514-Bromo-3-fluoro-2-methoxy-5-methylaniline

生成物 1

HCID 860974524-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

試薬・触媒・溶媒 1

HCID 57417360Sodium chloride; water溶媒

実験手順

N-iodosuccinimide (1.91 g, 8.5 mmol) was added to an acetic acid (40 ml) solution of 4-bromo-3-fluoro-2-methoxy-5-methylaniline (I-43) (1.90 g, 8.1 mmol), followed by stirring at room temperature for 67 hours. Saturated brine was added to the reaction liquid, followed by extraction twice with ethyl acetate, the organic layer was washed three times with saturated brine, dried over anhydrous magnesium sulfate.

後処理

  1. extractionfollowed by extraction twice with ethyl acetate
  2. washthe organic layer was washed three times with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate

出典と根拠

ORDレコード
ord-3933087f8a4a4ed49b2bc3f566af531a
出典データセット
uspto-grants-2010_06
特許番号
US07737166B2

反応ノート

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