Sodium Hydroxide → HCID 21401588、化合物

反応式

[OH:1][CH:2]([CH2:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1)[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])[S:7]([CH3:10])(=[O:9])=[O:8].C(OC(COC1C=CC(F)=CC=1)CCCN(CC#CCCCC(OC)=O)S(C)(=O)=O)(=O)C.[OH-].[Na+]>>[OH:1][CH:2]([CH2:22][O:23][C:24]1[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=1)[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][C:12]#[C:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])[S:7]([CH3:10])(=[O:9])=[O:8]

参加物

反応物 3

HCID 14798Sodium Hydroxide

HCID 21401586Ethyl 7-{N-[4-hydroxy-5-(4-fluorophenoxy)pentyl]methanesulfonamido}heptanoate

HCID 21401649HCID 21401649、化合物

生成物 1

HCID 21401588HCID 21401588、化合物

実験手順

The synthesis of this compound is carried out as described in Example 1, Step E except that the ethyl 7-{N-[4-hydroxy-5-(4-fluorophenoxy)pentyl]methanesulfonamido} -heptanoate is replaced by an equimolar amount of methyl 7-{N-[4-acetoxy-5-(4-fluorophenoxy)pentyl]methanesulfonamido}-hept- 5-ynoate and the amount of sodium hydroxide is doubled. The product of this reaction is the subject compound.

後処理

customThe synthesis of this compound

出典と根拠

ORDレコード: ord-bdfb3d3442144665beeae132fe157b0e
出典データセット: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03991106

反応ノート

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