Phosgene → HCID 178456444、化合物
反応式
Cl.C(NN)(C)C.N#CCl.[OH-].[Na+].[CH:12]([N:15]([C:17]#[N:18])[NH2:16])([CH3:14])[CH3:13].[C:19](Cl)(Cl)=[O:20]>O>[CH:12]([N:15]1[CH:17]=[N:18][C:19]([OH:20])=[N:16]1)([CH3:14])[CH3:13]Cl.C(NN)(C)C.N#CCl.[OH-].[Na+].[CH:12]([N:15]([C:17]#[N:18])[NH2:16])([CH3:14])[CH3:13].[C:19](Cl)(Cl)=[O:20]>O>[CH:12]([N:15]1[CH:17]=[N:18][C:19]([OH:20])=[N:16]1)([CH3:14])[CH3:13]
Into a solution of isopropylhydrazine hydrochloride in a mixture of 3 partsof water and one part of alcohol there is introduced, at a temperature of 10° C, an equivalent amount of cyanogen chloride, with a pH-range of 6.5 to 7 being maintained by addition of sodium hydroxide solution and checking with a pH-meter. The duration of the reaction is 1 hour. During the reaction, there precipitates a yellow oil from which there is obtained, by extraction with ether, the crude 1-isopropyl-cyano-hydrazine in a yield of 90% as oil. The crude product obtained in this way can be used directly for the further reaction with phosgene to give 1-isopropyl-3-hydroxy-1,2,4-triazole.
読み込み中…
